Kameyama Koichiro, Aoyamahifukakurinikku. (1999) Research on acne and development antiacne cosmetics. The effect of vitamin C on acne. Fragr J; vol. 27, no. 8, pp. 41-48. Journal Code: G0987B (Fig. 17, Ref. 2) CODEN: FUJAD7; ISSN: 0288-9803, Japan

Abstract:

Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on acne: acne is not infectious disease essentially, is a disease caused by reactive oxygen species resulting in excessive amount of sebum. 10% VC-PMG cream was effective in reducing skin pigmentation such as chloasma or post-inflammatory pigmentation resulting acne in some patients. Interestingly VC-PMG cream also reduced the degree of newly occurring ance. A biopsyed specimen from a patient with acne showed that 1) sebaceous glands in the dermis were surrounded by a lot of inflammatory cells chiefly composed by neutrophils with nuclear dust of those cells, 2) there was no evidence of bacterial infection, so that, there was no bacteria on the skin. These findings clearly suggest that acne is a disease caused by reactive oxygen species. Therefore the effect of VC-PMG on acne was studied, since VC-PMG has the effect to reduce the activity of reactive oxygen species. The result showed that 1)VC-PMG cream and/or VC-PMG solution was very effective on the therapy of acne, 2)the effect was increased when it was combined with iontophoresis of VC-PMG and/or chemical peeling. (author abst.)